Research Associate

Job Description:

As an R&D Scientist in the API Development team, you will be responsible for independently planning and executing the synthesis of drug intermediates and active pharmaceutical ingredients (APIs). The role involves literature research, route scouting, cost analysis, troubleshooting, and working closely with cross-functional teams to support scale-up and commercialization of APIs.

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Key Responsibilities

1. Molecule Assessment & Route Design:

Perform detailed literature surveys and identify synthetic routes using tools like SciFinder, Reaxys, and patents.

Conduct route feasibility studies and perform cost calculations (RTDC).

Provide technical inputs to R&D leadership for project planning and decision-making.

2. Synthesis Execution:

Plan and carry out multi-step synthesis of assigned molecules.

Optimize reaction conditions, isolate intermediates, and purify final compounds.

Maintain focus on yield, purity, and scalability of processes.

3. Project Management:

Execute and monitor multiple projects within stipulated timelines.

Troubleshoot synthetic or process issues proactively.

Ensure timely completion of assigned tasks.

4. Process Documentation & Compliance:

Generate specifications for raw materials, intermediates, and final APIs.

Prepare and review laboratory development reports and SOPs.

Maintain accurate lab notebooks and ensure GLP compliance.

5. Vendor & Lab Coordination:

Support vendor qualification processes by providing technical documents and test procedures.

Participate in lab validation and preparation of AMV (Analytical Method Validation) protocols.

6. Technical Support to Scale-Up:

Assist in the transfer of developed processes to pilot and commercial plant scale.

Troubleshoot issues during scale-up and ensure validation of processes in coordination with tech transfer teams.

7. Cross-functional Collaboration:

Coordinate with Analytical R&D, Regulatory Affairs, Quality Assurance, and Production teams.

Analyze reports from analytical departments and implement required changes in the synthesis plan.

8. Innovation & Continuous Improvement:

Continuously evaluate existing processes for improvement opportunities.

Drive innovations that reduce cost, time, and environmental impact.

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Key Skills & Competencies:

Strong knowledge of synthetic organic chemistry and reaction mechanisms

Proficiency in handling laboratory equipment and analytical instruments (HPLC, GC, NMR, etc.)

Sound documentation and regulatory understanding

Good communication and team collaboration skills

Problem-solving and troubleshooting mindset